Healthcare Startups funded by Y Combinator (YC) in the San Francisco Bay Area that are currently hiring 2025

We're a women’s health company making personalized reproductive health information more accessible, earlier in life. We make the same laboratory tests that were previously confined to fertility clinics more accessible for women at home. By arming women with powerful information about their reproductive health, Modern Fertility is closing the fertility information gap and enabling women to own the decisions impacting their bodies and futures. We've raised $22 million from Forerunner Ventures, Maveron, Union Square Ventures, First Round Capital, #Angels and Y Combinator.

SimplyInsured was founded with one mission: to eliminate fear from health insurance. By changing the way small business owners purchase health insurance with our 100% online platform, we’re transforming a $20 billion dollar industry and delighting thousands of customers. Our unique values-based culture (and extremely talented team) is our core competitive advantage, and each person on our team makes a direct, immediate impact on our business. We value transparency, feedback, bias to action, growth, and an obligation to dissent. Every opinion is respected, we hold each other to extremely high standards, we’re driven by the diversity in our backgrounds, and unified by 100% alignment on our mission. What’s best for the customer is the heart of everything we do, and our customer stories prove it: by changing health insurance we’re literally saving lives. Based in San Francisco, SimplyInsured was founded in 2012 and is back by Bessemer Venture Partners, Polaris Ventures, and Y-Combinator. If you’re up for the challenge of improving health insurance for millions of Americans, we’re just getting started, and we’re growing!

Healthcare needs good data. At PicnicHealth, we are building deep real-world datasets fueling cutting-edge research while giving patients control of their own medical record data. These complete, clinically-rich datasets produce unique insights — across dozens of diseases — to ultimately get the right treatments into patients’ hands faster. We work directly with patients and leverage state of the art machine learning to transform messy medical records into structured, research-ready datasets. To date we’ve helped tens of thousands of patients securely access their records and proactively contribute to advancing research in diseases that impacts their lives.

SmartSpot is a post Series-A stealth startup backed by Founders Fund and Khosla Ventures that uses computer vision to deliver an unparalleled fitness training experience to your home. Our unique hardware solution gives amazing trainers the ability to see their class participants in real time and deliver detailed advice that was previously only possible in person.

We enable people to live their best lives. As we succeed, there is more convenience, healthier communities and thriving businesses. We get medications to those who need them and improve information, access and management of their care and enable businesses to move online and gain access to consumers who need their services

The iSono Health platform combines automated 3D ultrasound technology with cloud computation and artificial intelligence to empower women and their physicians with early detection and monitoring of breast cancer. Our patented compact ultrasound scanner captures 3D images through automatic scanning of whole breast volume in 1 min. The device connects to a smartphone/tablet/laptop and is controlled by our mobile app. The data is transferred to a secure cloud for image processing and storage. Our machine learning algorithm uses acoustic biomarkers to identify abnormal masses. Our platform’s automated operation and software expands ultrasound use in point-of-care diagnostics as well as monitoring of breast health at home, walk-in and mobile clinics. iSono Health offers women and healthcare providers : Safety: No Radiation Actionable Feedback with AI Fast: 2min Scan Easy to Use

BillionToOne has developed a DNA molecular counter that increases the cell-free DNA diagnostics resolution by over 1,000 fold, which unlocks transformative improvements in prenatal screening and liquid biopsy for cancers. Unity Screen, BillionToOne's commercially available non-invasive prenatal test (NIPT), is the only NIPT that can assess fetal risk for both recessive conditions and aneuploidies from maternal blood. UNITY Screen continues to grow exponentially and is on its path to becoming the next standard-of-care, with an increasing number of publications showing its accuracy and advantages over other screening methods. We have also recently used our molecular counting technology to develop liquid biopsy tests, which have the potential to completely transform oncology care.

Out-of-pocket healthcare costs are skyrocketing and every day, people all across America are forced to make difficult decisions about their health. Lively is the benefits solutions provider that gets it right. We designed our solutions to take the guesswork out of managing benefits. And our innovative features are built to simplify benefits administration and evolve with your business. Managing wellness and wealth takes more than a series of transactions. By combining robust features with unparalleled service, we make benefits administration effortless, even when time and energy are limited. Experience benefits administration as it should be with Lively. Go to www.livelyme.com to learn about how HSAs other modern employee benefits can help you and your team.

Rev Genomics is a plant biotechnology company that provides breeders, growers, and retailers with novel cultivars to differentiate themselves in high value markets.

Modern Health is the leading mental wellness platform that combines clinically validated assessments, personalized stress management support, an international network of certified behavioral health coaches, and licensed therapists to deliver mental health support across a broad range of individual needs. Modern Health empowers employers to lead the charge in helping their employees be less stressed, more engaged, and happier through evidence-based technology and professional support. Modern Health has raised over $170M from top investors Battery Ventures, Kleiner Perkins, Founders Fund, and John Doerr and supports over 200 companies globally including Lyft, Pixar, SoFi, Credit Karma, Electronic Arts, Cooley, and Okta.

ZBiotics is a synthetic biology company founded in 2016 and headquartered in San Francisco, California. The company bioengineers probiotic bacteria for nutraceutical and other applications. They launched the world's first genetically engineered probiotic in 2019 – a probiotic that breaks down a toxic byproduct of alcohol. They are currently developing a pipeline of additional engineered probiotics for other consumer health applications.

Meru Health is an online provider for greater mental health with remote clinicians (licensed therapists & psychiatrists), a smartphone-based treatment program, a biofeedback wearable and an anonymous peer-support group. Meru Health is committed to evidence-based care and has published groundbreaking clinical outcomes in several peer-reviewed medical journals with Harvard & UC Davis. Meru Health has offices in San Mateo CA, Denver CO and Helsinki, Finland.

Bunkerhill is a Sequoia/Felicis/YC-backed company whose goal is to increase the adoption of AI in healthcare, in order to help doctors catch deadly diseases earlier. Bunkerhill Health has built a consortium of research institutions (Stanford, Johns Hopkins, Harvard, etc.), who develop and validate AI algorithms seamlessly under our legal umbrella (less than one week of setup time for a new project when using the Bunkerhill consortium, versus a year or more for projects outside the consortium). Bunkerhill then manages the FDA clearance and commercial sales process for the algorithms that these institutions develop and validate with us. We’ve signed commercial contracts and deployed algorithms with the world’s leading health systems—UCSF, Mayo Clinic, Georgetown/MedStar, and several others. These algorithms help doctors identify patients earlier than has otherwise been possible, leading to better treatment outcomes (early clinical screening for heart disease, pancreatic cancer, etc.) We’re backed by world class investors: Sequoia, Felicis, SVAngel, Optum Ventures, Max Levchin (co-founder of PayPal and Affirm), YC, DCVC, and Pacific8.

We help healthcare companies run their practices. Eligibility, BI, claims, patient payments? Shoot us an email at founders@aperohealth.com Apero is a Y-Combinator-backed startup based in San Francisco bringing transparency and ease to medical billing. As one of the top startups from the Summer 2019 Y Combinator batch, we have raised from well-known investors including the creator of Gmail Paul Buchheit and the founders of Doctor on Demand, Gusto and Reddit, and serve startups that have raised over $1B in Venture Capital. The founding team are Stanford CS and Berkeley grads and include the CTO of Doctor on Demand having helped raised $240m and process millions of video calls. We are also hiring for engineers and product-minded operations people interested in giving price transparency to patients and providers. We serve practices nationwide, and integrate with leading EHRs as well.

Pair Team cares for the highest-need Medicaid recipients through a community-led, virtual care model. We take responsibility for the whole person by addressing not just clinical needs, but also health-related social needs such as housing instability and food access. We partner with local community-based organizations like shelters and safety net providers to coordinate care alongside our multidisciplinary care team to improve the wellbeing of underserved individuals and communities.

Daybreak offers comprehensive and clinically-validated online mental health services designed for youth, like teletherapy, psychiatry and digital education. We partner with schools and pediatric groups to make access to services easy, and strive to deliver zero cost to the end consumer through insurance and government funding.

Auricle is a medical device company building a breakthrough neurostimulation implant to restore hearing in millions of patients who no longer benefit from hearing aids, get less than 60% on a word recognition test, but aren't prepared to make the jump to a cochlear implant. Our approach preserves remaining natural hearing through a reversible and less invasive surgery, addressing the key concerns that hold most patients back from getting a cochlear implant (currently the only treatment option for these patients). The company spun out of Stanford Biodesign having completed two acute human clinical studies demonstrating the approach will work. The team is now focused on developing their full implant system for their first clinical trial. Auricle addresses a currently unserved profile of hearing loss that affects a growing population of 3.5 million patients in the US and represents an immediately accessible $1.2B market opportunity with existing reimbursement.

38 million people suffer from heart rhythm disorders and are recommended to start medications that can save their lives, but require rigorous ECG monitoring to start and remain on these pills. SafeBeat Rx moves beyond diagnostics to guide these therapeutics, powered by our ML ECG software that integrates with existing FDA-cleared wearables to allow seamless physician approval of drug dosing, all from a mobile phone. We are a team of physicians, engineers, data scientists, and machine learning experts dedicated to using engineering to improve heart health.

Rinse is building the One Medical for dental. Beautiful studios, easy to book same day appointments, and anxiety-free care focused on prevention, not the upsell.

We build software to manage, analyze, and optimize bioprocessing data. Our initial customers are bio-industrial companies, who produce various products in bioreactors.

Adoption of Telehealth 1.0 has dropped to <5% because it's inefficient and unintelligent. Ankr uses generative AI to recreate functions of clinic staff including front desk, medical assistants and scribe. This allows Doctors to "spin-up" virtual clinics on-demand, anytime, anywhere. An average clinic using Ankr generates $1M in new revenue/year. We integrate with all top EHRs and work with all types of clinics in mid- to large-sized healthcare organizations.

Joon is an integrated pediatric digital health platform for kids, starting with behavior disorders like ADHD, autism, anxiety, and depression. In Joon, kids access a game-based digital therapeutic where they level up when they do real-life behaviors that are managed by parents and clinicians. Over the next 10 years, we plan on being the first-line vertically integrated digital treatment for pediatric behavior disorders, leveraging the first of its kind technology to drive behavior change.

Orchid is an AI-powered Electronic Health Record (EHR) for independent mental health professionals that saves them time, money, and frustration by integrating core administrative workflows, streamlining clinical processes, and automating manual flows.

One Codex is a data platform for applied microbial genomics, enabling new and valuable applications in clinical diagnostics, food safety, and biosecurity. Acquired by Invitae (NVTA) in February 2021. Spun out as an independent company in September 2022.

Loop Genomics provides long-read sequencing solutions across a diverse set of research and clinical applications. Our platform for long-read DNA sequencing transforms short-read DNA sequencers into long-read sequencing machines.

Able Health is the one platform physician organizations need to manage value-based programs. From calculating HEDIS and Medicare measures to engaging clinicians and health plans, managing value-based programs can take an army of administrators and IT staff. Able Health simplifies administration, customized to your specific programs, so you can ease today's reporting requirements and set your organization up for the future of healthcare reimbursements.

Clear Genetics is developing innovative, patient-centric software to thoughtfully integrate genetics into routine patient care. Our HIPAA-compliant platform offers an automated and comprehensive solution to deliver genetic services at scale. Clear Genetics serves leading health systems, clinics and commercial labs across the nation.

Waiting rooms suck. Insurance and the paperwork are worse. We are a team of doctors, developers, lawyers, designers, and more working to try to fix it. Using our app, and soon the website, you can access medical care online right now and be done in 5 minutes. No insurance, video, or phone calls necessary and most visits are under $20. You can chat with your doctor anytime and anywhere. Our services are currently available in Arizona, California, Connecticut, Florida, Georgia, Illinois, Montana, New York, Ohio, Pennsylvania, Rhode Island, Virginia and Washington, but don't worry the rest of the country coming soon. Here are the medical services we offer so far: - Acne Diagnosis, Treatment, and Prevention - High Cholesterol (Lipid) Testing and Treatment - Start or Refill Birth Control - Urinary Tract Infection (UTI) Testing and Treatment - Vitamin D Screening and Treatment - Pre-Diabetes Screening and Referral - Hepatitis C Screening and Referral - Female Condom Prescription - Help Quitting Smoking - Find Out Your Blood Type We are adding new services every week, so if you don't see what you need let us know. We want HeyDoctor and our partner health systems to be your first stop for healthcare and be your personal medical record.

Notable Labs is building a personalized drug discovery platform to identify treatment options for relapsed and refractory cancer patients — starting with blood cancer — to address the long tail of cancer treatment. We look at a person’s actual cancer cells, test combinations of FDA approved drugs, and see which combinations kill the cancer cells and leave the healthy cells alive. We focus on combinations because cancer is often difficult to target with just one drug and starting with a single drug can lead to resistant clones or relapse. We're building a highly automated lab in Foster City running on our custom software and are currently testing relapsed/refractory cancer patients as well as samples from a variety of pharma/biotech partnerships. https://www.notablelabs.com/careers